促甲状腺激素释放激素（TRH）作用后抑郁症患者的内分泌及行为变化。甲状腺激素预处理的影响。

Endocrine and behavioral changes in depression after thyrotropin-releasing hormone (TRH). Alteration by pretreatment with thyroid hormones.

作者信息

Loosen P T, Wilson I C, Prange A J

出版信息

J Affect Disord. 1980 Dec;2(4):267-78. doi: 10.1016/0165-0327(80)90028-2.

Abstract

The effects of pretreatment with a single dose of thyroid hormones (TH) on the subsequent endocrine and behavioral response to TRH was evaluated in unipolar depressed women. TH pretreatment altered neither serum levels of thyroid hormones nor the TRH-induced TSH response. It antagonized, however, the behavioral response to TRH. This was apparent in 2 self-assessment scales but not in an objective rating scale. Taken together the data suggest that (a) there is an impaired pituitary response to TH feedback in depressed patients; (b) TH pretreatment may affect self-assessment of behavioral effects of TRH in depression.

摘要

在单相抑郁女性中评估了单剂量甲状腺激素（TH）预处理对随后内分泌及对促甲状腺激素释放激素（TRH）行为反应的影响。TH预处理既未改变甲状腺激素的血清水平，也未改变TRH诱导的促甲状腺激素（TSH）反应。然而，它拮抗了对TRH的行为反应。这在2个自我评估量表中明显，但在客观评定量表中未出现。综合这些数据表明：（a）抑郁患者垂体对TH反馈的反应受损；（b）TH预处理可能影响抑郁症中TRH行为效应的自我评估。