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睾丸精原细胞瘤患者的生育能力(作者译)

[Fertility in patients with testicular seminoma (author's transl)].

作者信息

Kuber W, Lunglmayr G, Seitz W, Grauthoff H, Weissbach L

出版信息

Urologe A. 1980;19(5):272-5.

PMID:6774461
Abstract

In view of the excellent prognosis and the desire for children frequently expressed after post-operative healing, fertility studies were performed in 234 patients with seminoma of the tests. There already was a reduced sperm count before therapy in 39 out of 46 patients. The damage to spermatogenesis induced by radiotherapy can lead to azoospermia, cryptozoospermia and severe oligozoospermia in the first two years. The different irradiation techniques with the resulting burden on the residual testis are described. By appropriate irradiation adapted to the stage of the disease as well as by application of a testis guard, the damage to the residual testis can be reduced to the extent that restitution can be expected after two years. Four fathers produced healthy children within three to five years after the end of treatment.

摘要

鉴于精原细胞瘤患者术后愈合良好且常有生育需求,我们对234例睾丸精原细胞瘤患者进行了生育力研究。46例患者中有39例在治疗前精子计数就已降低。放疗对生精功能造成的损害在头两年可导致无精子症、隐匿精子症和严重少精子症。文中描述了不同的放疗技术及其对残余睾丸造成的负担。通过根据疾病分期采用合适的放疗方法以及使用睾丸保护装置,可将对残余睾丸的损害降低到两年后有望恢复的程度。4名患者在治疗结束后三到五年内生育了健康子女。

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