Karlov V A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1980;80(6):863-7.
On the basis of the information about 286 patients with a grave course of epilepsy, but showing an improvement as a result of more individualized treatment a number of today's problems concerning the therapy of this disease are discussed with reference to 102 of those patients. Of these problems the principal are: consideration of the pharmacodynamics and pharmacokinetics of antiepileptic drugs while solving the questions on their dosage, intervals between the doses and combined medication; specification of the character of petit mal (absence, pseudoabsence) with the purpose of individualization of the treatment; consideration of the therapy peculiarities in epilepsy of sleep and concomitance of epilepsy and hyposomnia.
基于286例癫痫重症患者的信息,这些患者因更具个体化的治疗而有所改善,本文参照其中102例患者讨论了当今该疾病治疗中的一些问题。这些问题中主要的有:在解决抗癫痫药物的剂量、给药间隔和联合用药问题时,要考虑其药效学和药代动力学;明确小发作(失神、假失神)的特征以实现治疗个体化;考虑睡眠性癫痫以及癫痫与失眠并存时的治疗特点。