Hagen C, Brandt M R, Kehlet H
Acta Endocrinol (Copenh). 1980 Jun;94(2):151-4. doi: 10.1530/acta.0.0940151.
The prolactin, LH, FSH, growth hormone and cortisol responses to surgical stress were studied in female patients receiving halothane (general) anaesthesia or epidural analgesia. Plasma cortisol, prolactin, and growth hormone concentrations increased during surgery, and post-operatively in patients operated under general anaesthesia, but not in patients operated during epidural analgesia. Gonadotrophin concentrations were unchanged in the general anaesthesia group until 9 h after stimulation when levels decreased slightly. In contrast plasma gonadotrophin levels decreased immediately after the administration of epidural analgesia and during the following 9 h. It is concluded that neurogenic blockade inhibits the anterior pituitary response to surgical stress.
在接受氟烷（全身）麻醉或硬膜外镇痛的女性患者中，研究了催乳素、促黄体生成素、促卵泡生成素、生长激素和皮质醇对手术应激的反应。手术期间以及接受全身麻醉手术的患者术后，血浆皮质醇、催乳素和生长激素浓度升高，但接受硬膜外镇痛手术的患者术后这些激素浓度未升高。全身麻醉组中促性腺激素浓度在刺激后9小时内未发生变化，之后略有下降。相比之下，硬膜外镇痛给药后及随后9小时内，血浆促性腺激素水平立即下降。结论是神经源性阻滞抑制垂体前叶对手术应激的反应。
