Carretero J, Sánchez F, Blanco E, Riesco J M, Sánchez-Franco F, Vázquez R
Department of Morphological Sciences, Cellular Biology and Pathology, University of Salamanca, Spain.
Anat Embryol (Berl). 1989;179(3):243-50. doi: 10.1007/BF00326589.
An ultrastructural and morphometric study was carried out on the adenohypophyseal mammotropic cells of rats treated intraventricularly with an acute dose (150 micrograms) of Met-enkephalin. In the female rats, clear features of cellular hyperactivity appeared after opioid administration. The changes affected the Golgi complex, the rough endoplasmic reticulum, the mature and immature secretory granules and the images of exocytosis. Such changes did not appear when naloxone was administered before the opioid, and naloxone induced an increase in the numerical density of lysosomal dense bodies with lipoid inclusions. In the male animals, administration of an identical dose of Met-enkephalin caused only a few significant changes, similar to those observed in the controls. It is concluded that Met-enkephalin administered intraventricularly causes evident modifications in the mammotropic cells of female rats whereas such changes in the male animals are not significant.
对经脑室注射急性剂量（150微克）甲硫氨酸脑啡肽处理的大鼠腺垂体促乳腺细胞进行了超微结构和形态计量学研究。在雌性大鼠中，给予阿片类药物后出现了明显的细胞活性增强特征。这些变化影响了高尔基体、粗面内质网、成熟和未成熟分泌颗粒以及胞吐作用的图像。在给予阿片类药物之前给予纳洛酮时，这些变化并未出现，且纳洛酮导致含类脂包涵体的溶酶体致密小体的数量密度增加。在雄性动物中，给予相同剂量的甲硫氨酸脑啡肽仅引起了一些与对照组相似的显著变化。得出的结论是，经脑室注射甲硫氨酸脑啡肽会导致雌性大鼠促乳腺细胞发生明显改变，而雄性动物中的此类变化并不显著。
