Lack of effect of oral pyridoxine on TRH and chlorpromazine induced prolactin secretion.

In view of the controversial action of pyridoxine on prolactin dynamics, the plasma prolactin response to TRF and chlorpromazine was evaluated in normal adults before and after one week of pyridoxine per os (750 mg daily). No statistically significant blunting effect of pyridoxine pretreatment could be demonstrated in either of both test procedures.