Titov V V
Arch Exp Veterinarmed. 1980;34(1):115-8.
A lyophilised live vaccine, developed on the basis of Listeria strain AUF (Serotype I), proved to provide adequate protection against all serotypes of listeriosis. The live vaccine was tested in field experiments over several years. Mortality among cattle, sheep, swine, and rabbit was considerably reduced in all immunisation areas, following several years of use in prophylaxis and after-care. Spectacular success was obtained from swine, with lethality having been lowered by the factor of 35. A live vaccine against brucellosis was developed on the basis of strain Brucella abortus 82. The properties of the strain are described. Its markedly pronounced immunogenicity is demonstrated in greater detail. Data are given on the use of the commercially available lyophilised vaccine which gave rates of success up to 100 per cent in certain contaminated areas. Work now is in progress on further optimisation of the vaccine and its large-scale manufacture at industrial level.
一种基于李斯特菌AUF菌株（血清型I）研制的冻干活疫苗，经证实能为所有血清型的李斯特菌病提供充分保护。这种活疫苗经过了数年的田间试验。在预防和后续护理中使用数年之后，所有免疫区域的牛、羊、猪和兔的死亡率都大幅降低。猪的效果尤为显著，致死率降低了35倍。一种基于流产布鲁氏菌82菌株研制的抗布鲁氏菌病活疫苗也已开发出来。文中描述了该菌株的特性，并更详细地展示了其显著的免疫原性。还给出了关于使用市售冻干疫苗的数据，在某些污染地区成功率高达100%。目前正在进一步优化该疫苗并在工业规模上进行大规模生产。
