活布鲁氏菌疫苗免疫生物学特性的比较研究。

Comparative study of the immunobiological properties of live brucellosis vaccines.

机构信息

Federal Center for Toxicological and Radiation Animal Safety, A Federal State Institute FCTRAS-VNIVI [All-Russian Research Veterinary Institute], 2 Nauchnyi proezd, Kazan, Tatarstan, Russia.

出版信息

Vaccine. 2010 Oct 1;28 Suppl 5:F35-40. doi: 10.1016/j.vaccine.2010.03.050. Epub 2010 Mar 31.

DOI:10.1016/j.vaccine.2010.03.050

PMID:20362201

Abstract

Findings from the comparative study of the immunobiological properties of live brucellosis vaccines in guinea pigs are presented in the article. Vaccines from strains Brucella abortus 19 (U.S.) and 82 (Russia), in the S and SR forms, respectively, exhibited the highest and most pronounced immunological efficacy, while vaccines from strains B. abortus 82-PS (in the RS form) and B. abortus RB-51 and 75/79-AB (in the R forms) exhibited the lowest. The live vaccine from strain B. abortus 82, together with a high immunological activity, possesses inagglutinogenic properties. The great advantage of this vaccine over the vaccine from strain B. abortus 19 is that after its use in animals the problem of the differential diagnosis of brucellosis becomes much simpler. The live vaccine from strain B. abortus 82 was adopted in veterinary practice in the Russian Federation; it is widely used for the targeted prevention of bovine brucellosis, but can also be used successfully for wild animals such as bison, deer, elk, and others.

摘要

本文介绍了在豚鼠中比较研究活布鲁氏菌病疫苗的免疫生物学特性的结果。分别以 S 和 SR 形式存在的菌株布鲁氏菌 abortus 19（美国）和 82（俄罗斯）的疫苗表现出最高和最明显的免疫效力，而分别以 RS 形式存在的菌株布鲁氏菌 abortus 82-PS 和布鲁氏菌 abortus RB-51 和 75/79-AB（R 形式）的疫苗则表现出最低的免疫效力。菌株布鲁氏菌 abortus 82 的活疫苗具有免疫原性，同时具有不凝集原性。与菌株布鲁氏菌 abortus 19 的疫苗相比，这种疫苗的一个很大的优势是，在动物中使用后，布鲁氏菌病的鉴别诊断问题变得简单得多。菌株布鲁氏菌 abortus 82 的活疫苗在俄罗斯联邦的兽医实践中被采用；它被广泛用于有针对性地预防牛布鲁氏菌病，但也可以成功地用于野牛、鹿、麋鹿等野生动物。