人类慢性白血病细胞中的表面免疫球蛋白
Surface immunoglobulins in human chronic leukemia cells.
作者信息
Harłozińska A, Noworolska A, Richter R, Becker M
出版信息
Arch Immunol Ther Exp (Warsz). 1980;28(1):127-43.
By means of the cytotoxic and immunofluorescence tests, frequency of various classes of immunoglobulins (IgG, IgA, IgM, IgD, IgE) and light chains was examined in peripheral pathologic blood cells of patients with chronic granulocytic and lymphatic leukemia. The dominant immunoglobulins were of the IgD and IgE classes. Light chains of both types were present in cells of chronic granulocytic leukemia, and kappa type in chronic lymphatic leukemia. Use of the method of resynthesis of digested immunoglobulins in vitro confirmed the monoclonal origin of chronic lymphatic leukemia in humans.
通过细胞毒性和免疫荧光试验，检测了慢性粒细胞白血病和淋巴细胞白血病患者外周病理血细胞中各类免疫球蛋白（IgG、IgA、IgM、IgD、IgE）及轻链的频率。主要的免疫球蛋白为IgD和IgE类。慢性粒细胞白血病细胞中两种类型的轻链均有存在，而慢性淋巴细胞白血病细胞中则为κ型轻链。体外消化免疫球蛋白再合成方法的应用证实了人类慢性淋巴细胞白血病的单克隆起源。
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