对轻度营养不良十至十二代的大鼠在不同发育阶段进行康复治疗的效果。

The effect of rehabilitation at different stages of development of rats marginally malnourished for ten to twelve generations.

Stewart R J, Sheppard H, Preece R, Waterlow J C

Br J Nutr. 1980 May;43(3):403-12. doi: 10.1079/bjn19800108.

Abstract

Rats which have been maintained for ten to twelve generations on diets of low protein value were rehabilitated in utero (group P), from birth (group F) and from 4 weeks of age (group W). 2. Group W showed little change in physique, behaviour or learning, indicating that for recovery to be effective refeeding must begin earlier. 3. Group F just failed to attain full physical recovery (90%) whereas group P overgrew by 18.6% in weight and 8.5% in length. 4. In a test designed to evaluate learning ability rehabilitated rats of groups P and F were significantly less successful than normal rats, but more successful than rats of group W or rats of the original undernourished colony. 5. Rehabilitation for a further two generations in groups F and P corrected any residual physical and behavioural defects but produced no further improvement on the Lashley (1938) jumping platform.

摘要

食用低蛋白价值饲料维持了十到十二代的大鼠，在子宫内（P组）、出生时（F组）和4周龄时（W组）进行了恢复喂养。2. W组在体格、行为或学习方面几乎没有变化，这表明为了有效恢复，重新喂食必须更早开始。3. F组未能完全恢复身体状态（90%），而P组体重超生长了18.6%，体长超生长了8.5%。4. 在一项旨在评估学习能力的测试中，P组和F组恢复喂养的大鼠比正常大鼠成功程度明显更低，但比W组大鼠或原始营养不良群体的大鼠更成功。5. F组和P组再进行两代的恢复喂养纠正了任何残留的身体和行为缺陷，但在拉什利（1938年）跳跃平台测试中没有进一步改善。