Lipper S, Wheeler M S, Jennette C
Cancer. 1980 Sep 15;46(6):1411-7. doi: 10.1002/1097-0142(19800915)46:6<1411::aid-cncr2820460621>3.0.co;2-l.
A 55-year-old female developed a rapidly fatal, infiltrative, bilateral pulmonary disease. Open lung biopsy and subsequent autopsy revealed diffuse involvement by a malignant lymphoproliferative condition showing a striking angiocentric and angioinvasive pattern. This feature, together with microscopic involvement of hilar lymph nodes, bone marrow, spleen, and other viscera suggested lymphomatous transformation of lymphomatoid granulomatosis (LYG). The paucity of necrosis and of the typical polymorphic infiltrate was at variance with the classical description of that condition; however, the bilaterality of the process and the distinctive angioinvasive growth pattern were unlike the typical primary pulmonary lymphoma. Plasmacytoid cells were observed both by light and electron microscopy. Immunohistochemicl evaluation characterized this disease as a monoclonal lymphoproliferative malignancy.
一名55岁女性患有一种迅速致命的浸润性双侧肺部疾病。开胸肺活检及随后的尸检显示，一种恶性淋巴增殖性疾病呈弥漫性累及，表现出显著的血管中心性和血管浸润性模式。这一特征，连同肺门淋巴结、骨髓、脾脏和其他内脏的显微镜下累及，提示淋巴瘤样肉芽肿病（LYG）发生了淋巴瘤转化。坏死灶和典型多形性浸润的缺乏与该疾病的经典描述不符；然而，病变的双侧性和独特的血管浸润性生长模式不同于典型的原发性肺淋巴瘤。光镜和电镜下均观察到浆细胞样细胞。免疫组织化学评估将该疾病特征化为一种单克隆淋巴增殖性恶性肿瘤。
