Conklin K A, Graham C W, Murad S, Randall F M, Katz R L, Cabalum T, Lieb S M, Brinkman C R
Obstet Gynecol. 1980 Oct;56(4):471-4.
Maternal and fetal hemodynamic effects and placental transfer of midazolam (RO 21-3981, Hoffman-LaRoche) and diazepam were studied in chronically instrumented pregnant ewes. Diazepam administration resulted in greater increases of maternal and fetal heart rates and maternal blood pressure, and greater alteration of total uterine blood flow than did administration of comparable doses of midazolam. Neither drug altered fetal mean arterial pressure or maternal and fetal respiratory gases. Although the absolute blood concentrations were higher, the fetal:maternal drug concentration ratios were consistently less for midazolam than for diazepam, suggesting less placental permeability of midazolam.
在长期植入监测装置的怀孕母羊中，研究了咪达唑仑（RO 21 - 3981，霍夫曼 - 罗氏公司）和地西泮对母胎血流动力学的影响以及胎盘转运情况。与给予同等剂量的咪达唑仑相比，给予地西泮后母羊和胎儿心率增加幅度更大，母体血压升高更明显，子宫总血流量改变也更大。两种药物均未改变胎儿平均动脉压以及母胎呼吸气体。尽管咪达唑仑的绝对血药浓度较高，但其胎儿与母体药物浓度比始终低于地西泮，提示咪达唑仑的胎盘通透性较低。
