Bouygues M, Modigliani R, Rambaud J C, Hautefeuille P, Bernier J J
Nouv Presse Med. 1980;9(31):2141-5.
The authors present a retrospective study of 11 patients who had suffered from a severe attack of ulcerative colitis with extensive undermining of the mucosa on barium enema. All patients were given corticosteroids and antibodies. Oral feeding was suspended in 7, and 3 received exclusive parenteral nutrition. In 2 cases medical treatment resulted in complete remission, but 9 patients underwent surgery (total proctocolectomy in 4, total colectomy with ileo-rectal anastomosis in 3, colostomy in 1 and exploratory laparotomy in 1). Six of the operated patients were followed up for 1 to 7 years and are now in good health; the remaining three died early in the post-operative period. Extensive mucosal undermining in ulcerative colitis is a factor of poor prognosis.
作者对11例溃疡性结肠炎重症发作且钡剂灌肠显示黏膜广泛破坏的患者进行了一项回顾性研究。所有患者均接受了皮质类固醇和抗体治疗。7例患者停止经口喂养，3例接受全胃肠外营养。2例患者经药物治疗后完全缓解，但9例患者接受了手术（4例行全直肠结肠切除术，3例行全结肠切除术加回肠直肠吻合术，1例行结肠造口术，1例行剖腹探查术）。6例接受手术的患者随访1至7年，目前健康状况良好；其余3例在术后早期死亡。溃疡性结肠炎中广泛的黏膜破坏是预后不良的一个因素。
