Hirsh D C, Knox S J, Conzelman G M, Wiger N
Am J Vet Res. 1978 Jul;39(7):1219-21.
Parmacokinetics of penicillin G was determined for the turkey. The study was prompted by the isolation of a sulfonamide-resistant strain of Pasteurella multocida from tissues of turkeys involved in an outbreak of fowl cholera and the subsequent discovery that little pharmacologic information was available concerning other antimicrobial agents in that species. Penicillin G was chosen for study because P multocida is susceptible to this antibiotic. The elimination of the antibiotic followed first-order kinetics, and the half-life was found to be 0.5 hours. Parenteral administration of benzathine-procaine penicillin G resulted in higher concentrations, which persisted for longer periods than did procaine or potassium salts of the antibiotic.
已测定了火鸡体内青霉素G的药代动力学。本研究的起因是从发生禽霍乱疫情的火鸡组织中分离出一株对磺胺类药物耐药的多杀性巴氏杆菌，随后发现关于该物种中其他抗菌药物的药理信息很少。选择青霉素G进行研究是因为多杀性巴氏杆菌对这种抗生素敏感。抗生素的消除符合一级动力学，半衰期为0.5小时。肌内注射苄星-普鲁卡因青霉素G产生的浓度更高，且持续时间比该抗生素的普鲁卡因盐或钾盐更长。
