家兔和恒河猴中谷氨酰胺酶毒性的临床生化方面
Clinical biochemical aspects of glutaminase toxicity in rabbits and Rhesus monkeys.
作者信息
Hambleton P, Benbough J E, Baskerville A, Harris-Smith P W
出版信息
Br J Exp Pathol. 1980 Apr;61(2):208-16.
Abstract
Treatment with a chemically modified glutaminase was lethal to rabbits and Rhesus monkeys at all but the lowest doses. Changes in the serum levels of triglycerides, glucose, creatinine, urea, cholesterol and protein and in the activities of some serum enzymes were the probable result of the development of lesions in liver, kidney and intestine observed at necropsy. Treatment with unmodified glutaminase induced similar changes in rabbits but not in Rhesus monkeys.
摘要
除最低剂量外，用化学修饰的谷氨酰胺酶治疗对家兔和恒河猴均具有致死性。尸检时观察到肝脏、肾脏和肠道出现病变，血清甘油三酯、葡萄糖、肌酐、尿素、胆固醇和蛋白质水平以及某些血清酶活性的变化可能是这些病变发展的结果。用未修饰的谷氨酰胺酶治疗在家兔中引起了类似变化，但在恒河猴中未引起类似变化。
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本文引用的文献
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Br J Exp Pathol. 1980 Apr;61(2):132-8.
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