Bacterial glutaminase in treatment of acute leukaemia.
作者信息
Spiers A S, Wade H E
出版信息
Br Med J. 1976 May 29;1(6021):1317-9. doi: 10.1136/bmj.1.6021.1317.
Abstract
A glutaminase-asparaginase enzyme from Achromobacter sp has antitumour activity in vitro and in animals. Glutaminase was administered in doses of 3500-20 000 IU/m2 body surface area/day to six patients with acute lymphoblastic leukaemia (ALL) and three patients with acute myeloid leukaemia (AML). The enzyme had a blood half life of 80 minutes but depletion of blood glutamine persisted for 12 hours after single doses. Seven patients, including four (two with AML and two with ALL) resistant to asparaginase, received repeated doses of glutaminase. Antileukaemic effects were observed in all seven; one elderly patient developed metabolic acidosis. Study of this new antileukaemic agent in patients with acute leukaemia at an earlier stage of their disease is now justified.
摘要
相似文献
1
Bacterial glutaminase in treatment of acute leukaemia.
Br Med J. 1976 May 29;1(6021):1317-9. doi: 10.1136/bmj.1.6021.1317.
2
Achromobacter L-glutaminase-L-asparaginase: human pharmacology, toxicology, and activity in acute leukemias.
Cancer Treat Rep. 1979 Jun;63(6):1019-24.
3
Clinical evaluation of succinylated Acinetobacter glutaminase-asparaginase in adult leukemia.
Cancer Treat Rep. 1982 Jul;66(7):1479-85.
4
Asparaginase Erwinia chrysanthemi effectively depletes plasma glutamine in adult patients with relapsed/refractory acute myeloid leukemia.
Cancer Chemother Pharmacol. 2018 Jan;81(1):217-222. doi: 10.1007/s00280-017-3459-6. Epub 2017 Nov 8.
5
L-glutaminase and L-asparaginase by extracorporeal route in acute lymphoblastic leukemia therapy.
Int J Artif Organs. 1981 Sep;4(5):244-8.
6
Therapeutic properties of a new glutaminase-asparaginase preparation and the influence of the lactate dehydrogenase-elevating virus.
Cancer Res. 1974 Feb;34(2):429-38.
7
Effect of succinylated Acinetobacter glutaminase-asparaginase treatment on an acute myeloid leukemia in the rat (BNML).
Eur J Cancer (1965). 1979 Aug;15(8):1061-3. doi: 10.1016/0014-2964(79)90294-9.
8
Amino acid utilization and urine protein excretion in children treated with succinylated Acinetobacter glutaminase-asparaginase.
Cancer Res. 1981 Jun;41(6):2056-62.
9
L-Asparaginase as potent anti-leukemic agent and its significance of having reduced glutaminase side activity for better treatment of acute lymphoblastic leukaemia.
Appl Biochem Biotechnol. 2012 Aug;167(8):2144-59. doi: 10.1007/s12010-012-9755-z. Epub 2012 Jun 9.
10
A phase I and pharmacodynamic evaluation of polyethylene glycol-conjugated L-asparaginase in patients with advanced solid tumors.
Cancer Chemother Pharmacol. 2001;47(1):83-8. doi: 10.1007/s002800000207.
引用本文的文献
1
Antarctic marine sediment as a source of filamentous fungi-derived antimicrobial and antitumor compounds of pharmaceutical interest.
Extremophiles. 2024 Mar 27;28(2):21. doi: 10.1007/s00792-024-01339-1.
2
Bio-prospecting the future in perspective of amidohydrolase L-glutaminase from marine habitats.
Appl Microbiol Biotechnol. 2021 Jul;105(13):5325-5340. doi: 10.1007/s00253-021-11416-6. Epub 2021 Jul 8.
3
Deprivation of glutamine in cell culture reveals its potential for treating cancer.
Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6964-6968. doi: 10.1073/pnas.1815968116. Epub 2019 Mar 15.
4
A broader view: microbial enzymes and their relevance in industries, medicine, and beyond.
Biomed Res Int. 2013;2013:329121. doi: 10.1155/2013/329121. Epub 2013 Sep 11.
5
Gene cloning, purification, and characterization of a novel peptidoglutaminase-asparaginase from Aspergillus sojae.
Appl Environ Microbiol. 2012 Aug;78(15):5182-8. doi: 10.1128/AEM.00765-12. Epub 2012 May 18.
6
Glutamine supplementation in sick children: is it beneficial?
J Nutr Metab. 2011;2011:617597. doi: 10.1155/2011/617597. Epub 2011 Nov 14.
7
Clinical biochemical aspects of glutaminase toxicity in rabbits and Rhesus monkeys.
Br J Exp Pathol. 1980 Apr;61(2):208-16.
8
Pathological features of glutaminase toxicity.
Br J Exp Pathol. 1980 Apr;61(2):132-8.
9
Marrow relapse on maintenance chemotherapy in childhood acute lymphoblastic leukaemia.
Br J Cancer. 1979 Dec;40(6):890-7. doi: 10.1038/bjc.1979.282.
本文引用的文献
1
In vivo and in vitro effects of the L-asparaginase fraction of guinea pig serum on the 6C3HED ascites lymphosarcoma.
Cancer Res. 1966 Dec;26(12):2451-60.
2
Suppression of murine leukemias by L-asparaginase. Incidence of sensitivity among leukemias of various types: comparative inhibitory activities of guinea pig serum L-asparaginase and Escherichia coli L-asparaginase.
J Exp Med. 1967 Jan 1;125(1):17-31. doi: 10.1084/jem.125.1.17.
3
Isolation, crystallization, and properties of Achromobacteraceae glutaminase-asparaginase with antitumor activity.
J Biol Chem. 1972 Jan 10;247(1):84-90.
4
Automated determination of bacterial asparaginase and glutaminase.
Anal Biochem. 1971 Nov;44(1):189-99. doi: 10.1016/0003-2697(71)90360-5.
5
In vitro cytocidal effect of L-glutaminase on leukaemic lymphocytes.
Nature. 1971 Jul 23;232(5308):265. doi: 10.1038/232265a0.
6
L-asparaginase.
Annu Rev Med. 1970;21:433-44. doi: 10.1146/annurev.me.21.020170.002245.
7
E. coli L-asparaginase in the treatment of leukemia and solid tumors in 131 children.
Cancer. 1970 Feb;25(2):306-20. doi: 10.1002/1097-0142(197002)25:2<306::aid-cncr2820250206>3.0.co;2-h.
8
Response to highly purified L-asparaginase during therapy of acute leukemia.
Cancer Res. 1969 Aug;29(8):1574-80.
9
Effect of L-glutaminase on transformation and DNA synthesis of normal lymphocytes.
Acta Haematol. 1972;48(1):12-5. doi: 10.1159/000208432.
10
Therapy with Erwinia L-asparaginase in children with acute leukemia after anaphylaxis to E. coli L-asparaginase.
Cancer. 1974 Mar;33(3):611-4. doi: 10.1002/1097-0142(197403)33:3<611::aid-cncr2820330303>3.0.co;2-u.
Zotero 插件