细菌谷氨酰胺酶在急性白血病治疗中的应用
Bacterial glutaminase in treatment of acute leukaemia.
作者信息
Spiers A S, Wade H E
出版信息
Br Med J. 1976 May 29;1(6021):1317-9. doi: 10.1136/bmj.1.6021.1317.
Abstract
A glutaminase-asparaginase enzyme from Achromobacter sp has antitumour activity in vitro and in animals. Glutaminase was administered in doses of 3500-20 000 IU/m2 body surface area/day to six patients with acute lymphoblastic leukaemia (ALL) and three patients with acute myeloid leukaemia (AML). The enzyme had a blood half life of 80 minutes but depletion of blood glutamine persisted for 12 hours after single doses. Seven patients, including four (two with AML and two with ALL) resistant to asparaginase, received repeated doses of glutaminase. Antileukaemic effects were observed in all seven; one elderly patient developed metabolic acidosis. Study of this new antileukaemic agent in patients with acute leukaemia at an earlier stage of their disease is now justified.
摘要
无色杆菌属的谷氨酰胺酶 - 天冬酰胺酶在体外和动物体内具有抗肿瘤活性。以3500 - 20000 IU/平方米体表面积/天的剂量给6例急性淋巴细胞白血病（ALL）患者和3例急性髓细胞白血病（AML）患者施用谷氨酰胺酶。该酶的血液半衰期为80分钟，但单次给药后血液谷氨酰胺的消耗持续12小时。7例患者，包括4例（2例AML和2例ALL）对天冬酰胺酶耐药的患者，接受了重复剂量的谷氨酰胺酶。所有7例患者均观察到抗白血病作用；1例老年患者出现代谢性酸中毒。现在有理由在急性白血病患者疾病的更早阶段对这种新的抗白血病药物进行研究。
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