Hambleton P, Baskerville A, Harris-Smith P W, Bailey N E
Br J Exp Pathol. 1978 Dec;59(6):630-9.
Grivet monkeys infected with virulent Francisella tularensis Strain Schu S4 showed significant early changes in serum levels of trace metals, triglycerides and activities of alkaline phosphatase, lactate dehydrogenase and alpha-hydroxybutyrate dehydrogenase. Free amino acid levels decreased slightly and there was a marked increase in the phenylalanine: tyrosine ratio. Serum lysozyme activity and seromucoid levels also increased. Kanamycin therapy produced remission of overt signs but the changes in blood constituents were less readily affected. Immunization with the live vaccine strain of F. tularensis induced transient responses similar to those resulting from Schut S4 infection. Immunized monkeys subsequently challenged with the virulent Schu S4 strain showed no clinical signs or marked changes in blood constituents.
感染强毒土拉弗朗西斯菌舒S4菌株的灰沼狸血清中微量金属、甘油三酯水平以及碱性磷酸酶、乳酸脱氢酶和α-羟丁酸脱氢酶活性出现显著早期变化。游离氨基酸水平略有下降，苯丙氨酸与酪氨酸比值显著升高。血清溶菌酶活性和血清类黏蛋白水平也升高。卡那霉素治疗使明显症状缓解，但血液成分变化较难受到影响。用土拉弗朗西斯菌活疫苗株免疫诱导出与舒S4感染产生的类似短暂反应。随后用强毒舒S4菌株攻击的免疫猴子未出现临床症状，血液成分也无明显变化。
