Adams W H, Rufo R A, Talarico L, Silverman S L, Brauer M J
Ann Intern Med. 1978 Aug;89(2):207-11. doi: 10.7326/0003-4819-89-2-207.
Five young male heroin users presented with a syndrome resembling acute immune thrombocytopenic purpura. Although a viral, autoimmune, or toxic origin cannot be conclusively excluded at present, data are most consistent with the hypothesis that the thrombocytopenia was due to a drug-related immunologic mechanism that resulted in peripheral platelet destruction. Epidemiologic considerations suggest the common agent involved in their illnesses was present in the heroin they used. Although glucocorticoid therapy was followed by clinical recovery in four of the five patients (one was lost to follow-up), it is not certain that this represented a causal relation.
五名年轻男性海洛因使用者出现了类似急性免疫性血小板减少性紫癜的综合征。尽管目前不能完全排除病毒、自身免疫或中毒性病因，但现有数据最符合以下假设：血小板减少是由于药物相关的免疫机制导致外周血小板破坏。流行病学因素表明，导致他们患病的常见因素存在于他们所使用的海洛因中。虽然五名患者中有四名在接受糖皮质激素治疗后临床症状缓解（一名失访），但尚不能确定这两者之间存在因果关系。
