Christie D J, Walker R H, Kolins M D, Wilner F M, Aster R H
Arch Intern Med. 1983 Jun;143(6):1174-5.
Profound thrombocytopenia developed in a 22-year-old man after intravenous use of heroin. A high-titer, quinine-dependent, platelet-specific antibody was detected in his serum using lysis of normal platelets labeled with chromium 51 and an electroimmunoassay for measurement of platelet-associated IgG. The antibody was specific for quinine and failed to react with platelets in the presence of quinidine hydrochloride or two structural analogues of heroin. Quinine, a common adulterant found in heroin, was detected in the patient's blood and urine. On the basis of these observations, the patient was judged to have quinine-induced immunologic thrombocytopenia. To our knowledge, this report is the first to confirm that quinine used as an adulterant can induce immunologic thrombocytopenia following an injection of heroin.
一名22岁男子静脉注射海洛因后出现严重血小板减少症。利用用51铬标记的正常血小板裂解以及用于测量血小板相关IgG的电免疫测定法，在其血清中检测到高滴度、奎宁依赖性、血小板特异性抗体。该抗体对奎宁具有特异性，在存在盐酸奎尼丁或海洛因的两种结构类似物时不与血小板发生反应。在患者的血液和尿液中检测到奎宁，奎宁是海洛因中常见的掺假物。基于这些观察结果，判定该患者患有奎宁诱导的免疫性血小板减少症。据我们所知，本报告首次证实用作掺假物的奎宁在注射海洛因后可诱发免疫性血小板减少症。
