Sansom L N, Beran R C, Schapel G J
Med J Aust. 1980 Aug 23;2(4):212. doi: 10.5694/j.1326-5377.1980.tb112200.x.
Displacement of phenytoin from plasma proteins by valproate causes a reduction in total serum phenytoin levels. However, no adjustment of phenytoin dosage is warranted, unless clinically indicated, since the free phenytoin levels remain unchanged.
丙戊酸盐使苯妥英从血浆蛋白上置换下来，导致血清苯妥英总水平降低。然而，除非有临床指征，否则无需调整苯妥英剂量，因为游离苯妥英水平保持不变。
