丙戊酸钠对苯妥英钠血浆蛋白结合率的影响。
Effect of sodium valproate on plasma protein binding of diphenylhydantoin.
作者信息
Patsalos P N, Lascelles P T
出版信息
J Neurol Neurosurg Psychiatry. 1977 Jun;40(6):570-4. doi: 10.1136/jnnp.40.6.570.
Abstract
In vivo and in vitro experimental data are presented in support of the hypothesis that sodium valproate displaces diphenylhydantoin (DPH) from plasma protein binding sites. This interaction could have important practical implications in the management of patients on combined therapy with these two drugs. Acute neurological features of DPH intoxication may be precipitated as a result of an increased free (pharmacologically active) fraction, which would not be detected by routine plasma DPH estimations since these reflects largely the bound fraction.
摘要
现提供体内和体外实验数据，以支持丙戊酸钠从血浆蛋白结合位点置换苯妥英（DPH）这一假说。这种相互作用在使用这两种药物进行联合治疗的患者管理中可能具有重要的实际意义。由于游离（药理活性）部分增加，可能会引发苯妥英中毒的急性神经学特征，而常规血浆苯妥英测定无法检测到这种增加，因为这些测定主要反映的是结合部分。
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