促甲状腺激素释放激素——刺激胃酸分泌的中枢神经系统作用。

Thyrotropin-releasing hormone--CNS action to stimulate gastric acid secretion.

作者信息

Taché Y, Vale W, Brown M

出版信息

Nature. 1980 Sep 11;287(5778):149-51. doi: 10.1038/287149a0.

Abstract

Much physiological and pharmacological evidence has accumulated to suggest that the autonomic nervous system has an important role in the peripheral modulation of gastric secretion, although the neurochemical mediators in the brain which initiate or modulate autonomic input are poorly understood. Recently, the demonstration that some oligopeptides present in mammalian brain act in the central nervous system (CNS) to influence profoundly glucoregulation, thermoregulation, blood pressure, sympathetic outflow, muscular activity of gut and stress-induced gastric haemorrhagic lesions have led us to examine a possible role for some of these endogenous brain oligopeptides as chemical messengers involved in the CNS modulation of gastric secretion. We report here that thyrotropin-releasing hormone (TRH) acts within the CNS to elicit a vagus-dependent stimulation of gastric acid secretion.

摘要

大量生理学和药理学证据不断积累，表明自主神经系统在胃分泌的外周调节中起重要作用，尽管启动或调节自主神经输入的脑内神经化学介质仍知之甚少。最近，有证据表明哺乳动物脑内存在的一些寡肽在中枢神经系统（CNS）中发挥作用，深刻影响血糖调节、体温调节、血压、交感神经输出、肠道肌肉活动以及应激性胃出血性病变，这促使我们研究这些内源性脑寡肽中的一些作为参与CNS调节胃分泌的化学信使的可能作用。我们在此报告，促甲状腺激素释放激素（TRH）在CNS内发挥作用，引发依赖迷走神经的胃酸分泌刺激。