Nüsslein-Volhard C, Wieschaus E
Nature. 1980 Oct 30;287(5785):795-801. doi: 10.1038/287795a0.
In systematic searches for embryonic lethal mutants of Drosophila melanogaster we have identified 15 loci which when mutated alter the segmental pattern of the larva. These loci probably represent the majority of such genes in Drosophila. The phenotypes of the mutant embryos indicate that the process of segmentation involves at least three levels of spatial organization: the entire egg as developmental unit, a repeat unit with the length of two segments, and the individual segment.
在对黑腹果蝇胚胎致死突变体的系统性搜寻中，我们鉴定出了15个基因座，这些基因座发生突变时会改变幼虫的体节模式。这些基因座可能代表了果蝇中此类基因的大部分。突变胚胎的表型表明，体节形成过程至少涉及三个空间组织层次：作为发育单位的整个卵、长度为两个体节的重复单位以及单个体节。
