Burton D R, Boyd J, Brampton A D, Easterbrook-Smith S B, Emanuel E J, Novotny J, Rademacher T W, van Schravendijk M R, Sternberg M J, Dwek R A
Nature. 1980 Nov 27;288(5789):338-44. doi: 10.1038/288338a0.
We propose that, the binding site for the complement subcomponent Clq on immunoglobulin G involves the last two (C-terminal) beta-strands of the C gamma 2 domain. This region contains a large number of accessible and highly conserved charged residues and charge is postulated as an important component of the Clq-IgG interaction. The conclusions are reached on the basis of accessibility and sequence conservation analyses of C gamma 2 amino acid residues, the use of specific inhibitors and chemical modification studies.
我们提出，免疫球蛋白G上补体亚成分C1q的结合位点涉及Cγ2结构域的最后两条（C末端）β链。该区域含有大量可及的且高度保守的带电荷残基，并且电荷被假定为C1q-IgG相互作用的一个重要组成部分。这些结论是基于对Cγ2氨基酸残基的可及性和序列保守性分析、使用特异性抑制剂以及化学修饰研究而得出的。
