Jørgensen T, Hannestad K
Nature. 1980 Nov 27;288(5789):396-7. doi: 10.1038/288396a0.
Immunoglobulins function as antigen receptors of B lymphocytes and as effector molecules for elimination of foreign antigens. Recently, other functions have been revealed: for example, idiotypes (antigenic sites of variable (V) domains) bound on the surface of plasmacytomas can act as tumour-specific transplantation antigens. Moreover, optimal maturation of B lymphocytes of a given idiotype into antibody-secreting cells seems to require assistance from two different kinds of helper T cells (Th), one bearing receptors complementary or similar to that idiotype, and another that recognizes the antigen. To learn more about recognition of V regions by Th, we have used V-domains of the immunoglobulin A (IgA) (lambda 2) myeloma protein M315 produced by the BALB/c plasmacytoma MOPC315 (ref. 7) as carriers for anti-hapten responses. We report here that the Th response to the V-domain of the heavy chain (VH) and the light chain (VL) of M315 seems to be under H--2-linked immune response (IR) gene control.
免疫球蛋白作为B淋巴细胞的抗原受体以及清除外来抗原的效应分子发挥作用。最近，其他功能也被揭示出来：例如，浆细胞瘤表面结合的独特型（可变（V）结构域的抗原位点）可作为肿瘤特异性移植抗原。此外，给定独特型的B淋巴细胞向抗体分泌细胞的最佳成熟似乎需要两种不同的辅助性T细胞（Th）的协助，一种带有与该独特型互补或相似的受体，另一种识别抗原。为了更多地了解Th对V区的识别，我们使用了由BALB/c浆细胞瘤MOPC315（参考文献7）产生的免疫球蛋白A（IgA）（λ2）骨髓瘤蛋白M315的V结构域作为抗半抗原反应载体。我们在此报告，对M315重链（VH）和轻链（VL）V结构域的Th反应似乎受H-2连锁免疫反应（IR）基因控制。
