辅助性T细胞识别位于同源骨髓瘤蛋白轻链可变区肽段88 - 114/117上的独特型表位（315）。
T helper cells recognize an idiotope located on peptide 88-114/117 of the light chain variable domain of an isologous myeloma protein (315).
作者信息
Jørgensen T, Bogen B, Hannestad K
出版信息
J Exp Med. 1983 Dec 1;158(6):2183-8. doi: 10.1084/jem.158.6.2183.
Abstract
Isolated variable region light chain 315 (VL-315), the VL domain of a myeloma protein of BALB/c origin, induces T cells of BALB/c (H-2d) mice that help the adoptive secondary anti-4-hydroxy-3-iodo-5-nitrophenylacetyl (NIP) antibody response to NIP-Fab315. The location of the epitope recognized by helper cells was examined with two fragments of VL-315, obtained by cleavage with cyanogen bromide at Met 87. Both N-terminal fragment 1-86 and C-terminal fragment 88-114/117 elicited BALB/c antibodies that bound to the respective fragments and to VL-315. By contrast, only fragment 88-114/117, which consists of the third hypervariable region, J region, and 5-7 amino acids of the C region, induced helper cells that augmented the anti-NIP response to NIP-Fab 315.
摘要
源自BALB/c的骨髓瘤蛋白的可变区轻链315（VL-315）可诱导BALB/c（H-2d）小鼠的T细胞，这些T细胞有助于对NIP-Fab315产生继发性抗4-羟基-3-碘-5-硝基苯乙酰（NIP）抗体反应。用通过在Met 87处用溴化氰切割获得的VL-315的两个片段来检测辅助性T细胞识别的表位位置。N端片段1-86和C端片段88-114/117均能诱导BALB/c抗体，这些抗体能与各自的片段以及VL-315结合。相比之下，仅由第三个高变区、J区和C区的5-7个氨基酸组成的片段88-114/117能诱导辅助性T细胞，增强对NIP-Fab 315的抗NIP反应。
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