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1
T helper cells recognize an idiotope located on peptide 88-114/117 of the light chain variable domain of an isologous myeloma protein (315).辅助性T细胞识别位于同源骨髓瘤蛋白轻链可变区肽段88 - 114/117上的独特型表位（315）。
J Exp Med. 1983 Dec 1;158(6):2183-8. doi: 10.1084/jem.158.6.2183.
2
T helper cell recognition of idiotopes on lambda 2 light chains of M315 and T952: evidence for dependence on somatic mutations in the third hypervariable region.辅助性T细胞对M315和T952的λ2轻链独特型决定簇的识别：依赖于第三高变区体细胞突变的证据。
Eur J Immunol. 1985 Mar;15(3):278-81. doi: 10.1002/eji.1830150313.
3
Specificity of antibody and helper T-cell responses to the isologous myeloma protein W3129 and its subunits.抗体及辅助性T细胞对同源骨髓瘤蛋白W3129及其亚基反应的特异性
Mol Immunol. 1984 Jul;21(7):653-61. doi: 10.1016/0161-5890(84)90051-8.
4
Recognition of lambda 1 and lambda 2 murine light chains by carrier-specific isologous T helper cells; effect of L-H chain assembly.载体特异性同源T辅助细胞对λ1和λ2小鼠轻链的识别；L-H链组装的影响。
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The T lymphocyte response to syngeneic lambda 2 light chain idiotopes. Significance of individual amino acids revealed by variant lambda 2 chains and idiotope-mimicking chemically synthesized peptides.T淋巴细胞对同基因λ2轻链独特型表位的反应。变异λ2链和模拟独特型表位的化学合成肽所揭示的个别氨基酸的意义。
Eur J Immunol. 1986 Aug;16(8):889-93. doi: 10.1002/eji.1830160803.
6
H-2-linked Ir genes have a striking influence on the immunogenicity of idiotopes of myeloma protein 315 for T helper cells.与H-2相关的Ir基因对骨髓瘤蛋白315的独特型针对T辅助细胞的免疫原性有显著影响。
Scand J Immunol. 1985 Feb;21(2):183-7. doi: 10.1111/j.1365-3083.1985.tb01418.x.
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A small hypervariable segment in the variable domain of an immunoglobulin light chain stimulates formation of anti-idiotypic suppressor T cells.免疫球蛋白轻链可变域中的一个小的高变区刺激抗独特型抑制性T细胞的形成。
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5396-400. doi: 10.1073/pnas.79.17.5396.
8
Somatic mutations in the variable region of the lambda 2 chain of M315 suppression of antibodies to the idiotype of M315.M315抗体独特型的M315抑制的λ2链可变区中的体细胞突变。
Biken J. 1985 Dec;28(3-4):51-8.
9
Immunization with the light chain and the VL domain of the isologous myeloma protein 315 inhibits growth of mouse plasmacytoma MOPC315.用同源骨髓瘤蛋白315的轻链和VL结构域进行免疫可抑制小鼠浆细胞瘤MOPC315的生长。
Scand J Immunol. 1980;11(1):29-35. doi: 10.1111/j.1365-3083.1980.tb00205.x.
10
Regulatory idiotopes. Induction of idiotype-recognizing helper T cells by free light and heavy chains.调节性独特型表位。游离轻链和重链诱导识别独特型的辅助性T细胞。
J Exp Med. 1984 Feb 1;159(2):623-8. doi: 10.1084/jem.159.2.623.

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Idiotope-Driven T-Cell/B-Cell Collaboration-Based T-Cell Epitope Prediction Using B-Cell Receptor Repertoire Sequences in Infectious Diseases.基于 B 细胞受体库序列的传染病中 idiotope 驱动的 T 细胞/B 细胞协同作用的 T 细胞表位预测。
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Immunogenicity of Isogenic IgG in Aggregates and Immune Complexes.同基因IgG在聚集体和免疫复合物中的免疫原性。
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Targeted DNA vaccines for enhanced induction of idiotype-specific B and T cells.针对独特型特异性 B 和 T 细胞的靶向 DNA 疫苗。
Front Oncol. 2012 Oct 30;2:154. doi: 10.3389/fonc.2012.00154. eCollection 2012.
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Targeting human B-cell malignancies through Ig light chain-specific cytotoxic T lymphocytes.通过针对免疫球蛋白轻链的细胞毒性 T 淋巴细胞靶向人类 B 细胞恶性肿瘤。
Clin Cancer Res. 2011 Sep 15;17(18):5945-52. doi: 10.1158/1078-0432.CCR-11-0970. Epub 2011 Aug 3.
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Immunotherapy in multiple myeloma: Id-specific strategies suggested by studies in animal models.多发性骨髓瘤中的免疫疗法：动物模型研究提出的针对个体独特型的策略
Cancer Immunol Immunother. 2004 Sep;53(9):759-69. doi: 10.1007/s00262-004-0504-1. Epub 2004 Apr 15.
6
Differences in kappa to lambda (kappa:lambda) ratios of serum and urinary free light chains.血清和尿游离轻链的κ与λ（κ:λ）比值差异。
Clin Exp Immunol. 1998 Feb;111(2):457-62. doi: 10.1046/j.1365-2249.1998.00487.x.
7
Clinical relapse in systemic lupus erythematosus: correlation with antecedent elevation of urinary free light-chain immunoglobulin.系统性红斑狼疮的临床复发：与尿游离轻链免疫球蛋白先前升高的相关性。
J Clin Immunol. 1989 Jul;9(4):338-50. doi: 10.1007/BF00918666.
8
Fine specificity analysis of idiotype-specific suppressor factors that block a delayed-type hypersensitivity response to M315: evidence supporting a role for somatic mutations in the variable region of the lambda 2 chain of M315.对阻断针对M315的迟发型超敏反应的独特型特异性抑制因子的精细特异性分析：支持M315的λ2链可变区体细胞突变起作用的证据。
Immunology. 1986 Nov;59(3):365-72.

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The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.对半抗原-蛋白质偶联物二次应答中的载体效应。II. 细胞协作。
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Helper T cell recognition of the variable domains of a mouse myeloma protein (315). Effect of the major histocompatibility complex and domain conformation.辅助性T细胞对小鼠骨髓瘤蛋白可变区的识别（315）。主要组织相容性复合体和结构域构象的影响。
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A small hypervariable segment in the variable domain of an immunoglobulin light chain stimulates formation of anti-idiotypic suppressor T cells.免疫球蛋白轻链可变域中的一个小的高变区刺激抗独特型抑制性T细胞的形成。
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5396-400. doi: 10.1073/pnas.79.17.5396.
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Recognition of lambda 1 and lambda 2 murine light chains by carrier-specific isologous T helper cells; effect of L-H chain assembly.载体特异性同源T辅助细胞对λ1和λ2小鼠轻链的识别；L-H链组装的影响。
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An active antibody fragment (Fv) composed of the variable portions of heavy and light chains.一种由重链和轻链可变部分组成的活性抗体片段（Fv）。
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辅助性T细胞识别位于同源骨髓瘤蛋白轻链可变区肽段88 - 114/117上的独特型表位（315）。

T helper cells recognize an idiotope located on peptide 88-114/117 of the light chain variable domain of an isologous myeloma protein (315).

作者信息

Jørgensen T, Bogen B, Hannestad K

出版信息

J Exp Med. 1983 Dec 1;158(6):2183-8. doi: 10.1084/jem.158.6.2183.

DOI:10.1084/jem.158.6.2183
PMID:6227679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187159/
Abstract

Isolated variable region light chain 315 (VL-315), the VL domain of a myeloma protein of BALB/c origin, induces T cells of BALB/c (H-2d) mice that help the adoptive secondary anti-4-hydroxy-3-iodo-5-nitrophenylacetyl (NIP) antibody response to NIP-Fab315. The location of the epitope recognized by helper cells was examined with two fragments of VL-315, obtained by cleavage with cyanogen bromide at Met 87. Both N-terminal fragment 1-86 and C-terminal fragment 88-114/117 elicited BALB/c antibodies that bound to the respective fragments and to VL-315. By contrast, only fragment 88-114/117, which consists of the third hypervariable region, J region, and 5-7 amino acids of the C region, induced helper cells that augmented the anti-NIP response to NIP-Fab 315.

摘要

源自BALB/c的骨髓瘤蛋白的可变区轻链315（VL-315）可诱导BALB/c（H-2d）小鼠的T细胞，这些T细胞有助于对NIP-Fab315产生继发性抗4-羟基-3-碘-5-硝基苯乙酰（NIP）抗体反应。用通过在Met 87处用溴化氰切割获得的VL-315的两个片段来检测辅助性T细胞识别的表位位置。N端片段1-86和C端片段88-114/117均能诱导BALB/c抗体，这些抗体能与各自的片段以及VL-315结合。相比之下，仅由第三个高变区、J区和C区的5-7个氨基酸组成的片段88-114/117能诱导辅助性T细胞，增强对NIP-Fab 315的抗NIP反应。