Rahilly P M
Pediatrics. 1980 Nov;66(5):685-9.
The effects of breathing 100% O2, 2% CO2, and 0.5% CO2 on the cranial blood flow of the normal human baby were investigated. A mercury in Silastic strain gauge was placed around the occipital head circumference (OFC) of a sleeping infant, and jugular flow was measured using venous occlusion plethysmography. Cranial flow was calculated using formulas derived from an electrical model. In matched sleep states cranial blood flow fell with 100% O2 (mean from eight babies = 32.8%), and rose with 2% CO2 (mean from seven babies = 40.6%). With 0.5% CO2 the flow rose in three babies and did not change in another four. These results indicate the extreme sensitivity of cerebral vasculature to the nature of the ambient gas.
研究了呼吸100%氧气、2%二氧化碳和0.5%二氧化碳对正常人类婴儿颅血流量的影响。将硅橡胶应变片式汞传感器置于睡眠婴儿的枕部头围（OFC）周围，采用静脉阻塞体积描记法测量颈静脉血流。使用从电模型推导的公式计算颅血流量。在匹配的睡眠状态下，100%氧气吸入时颅血流量下降（八名婴儿的平均值 = 32.8%），2%二氧化碳吸入时颅血流量上升（七名婴儿的平均值 = 40.6%）。吸入0.5%二氧化碳时，三名婴儿的血流量上升，另外四名婴儿的血流量没有变化。这些结果表明脑血管系统对环境气体性质极为敏感。
