早产儿出生时的吸氧与长时间脑血管收缩
Oxygen at birth and prolonged cerebral vasoconstriction in preterm infants.
作者信息
Lundstrøm K E, Pryds O, Greisen G
机构信息
Department of Neonatology, National University Hospital, Copenhagen, Denmark.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1995 Sep;73(2):F81-6. doi: 10.1136/fn.73.2.f81.
To determine if the use of oxygen in the delivery room influences subsequent global cerebral blood flow (CBF), 70 infants of gestational age of less than 33 completed weeks were randomly assigned to receive room air (group I) or 80% oxygen (group II) during the initial stabilisation at birth. In group I supplemental oxygen was administered on clinical indications, when required. After being admitted to the neonatal intensive care unit all infants were treated according to our normal practice. At a postnatal age of 2 hours CBF was measured by xenon clearance. Seventy four per cent of the infants in group I were successfully stabilised without the need for supplemental oxygen. CBF was significantly higher in group I than in group II (CBF median (interquartile range): 15.9 (13.6-21.9) v 12.2 (10.7-13.8) ml/100 g/minute). Differences in oxygen exposure seemed to be the only explanation for the differences in CBF. No differences in short term outcome were found between the groups.
为了确定在产房使用氧气是否会影响随后的全脑血流量（CBF），将70名孕周小于33周的婴儿在出生后初始稳定期随机分为两组，一组接受室内空气（I组），另一组接受80%氧气（II组）。I组在有临床指征时按需给予补充氧气。所有婴儿入住新生儿重症监护病房后均按照我们的常规做法进行治疗。在出生后2小时，通过氙清除法测量CBF。I组中74%的婴儿无需补充氧气即可成功稳定。I组的CBF显著高于II组（CBF中位数（四分位间距）：15.9（13.6 - 21.9）对12.2（10.7 - 13.8）ml/100g/分钟）。氧气暴露的差异似乎是CBF差异的唯一解释。两组之间在短期结局方面未发现差异。
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