Pfannenstiel P
Z Gesamte Inn Med. 1980 May 15;35(10):413-8.
The free fractions of the thyroid hormone further the metabolism of the body cells and regulate the synthesis of the thyroid hormone. Once the level of FT3 and FT4 decreases. With the help of a liberation of the hormone stimulating the thyroid gland from the anterior lobe of the pituitary gland the lack of thyroid hormone is corrected. The synthesis and secretion of the thyroid gland stimulating hormone is induced by the thyreotropin releasing hormone which is given by the hypothalamus. Moreover, the organism is able as needed to carry out the monodiodation of LT4 to biologically active LT3 or biologically inactive so-called revers T3 (RT3). The estimation of thyroid gland stimulating hormone before and 30 minutes after intravenous application of thyreotropin releasing hormone has its main importance for the early recognition of a disturbance of the regulating circle hypophysis-thyroid gland, above all in the diagnosis of clinically not yet manifest clinical pictures, such as the latent hypothyreosis and the latent hyperthyreosis, respectively (Basedow hyperthyreosis and thyroidal autonomy). According to the questioning the estimations of the levels of the thyroid hormones and of the thyroid gland stimulating hormone should be used stepwise.
甲状腺激素的游离部分促进身体细胞的新陈代谢并调节甲状腺激素的合成。一旦FT3和FT4水平下降，在垂体前叶释放刺激甲状腺的激素的帮助下，甲状腺激素的缺乏得以纠正。促甲状腺激素的合成和分泌由下丘脑分泌的促甲状腺激素释放激素诱导。此外，机体能够根据需要将LT4单碘化，生成生物活性的LT3或生物无活性的所谓反T3（RT3）。静脉注射促甲状腺激素释放激素前及注射后30分钟测定促甲状腺激素，对于早期识别垂体-甲状腺调节环路紊乱至关重要，尤其是在诊断临床上尚未显现的临床表现时，如分别为潜在性甲状腺功能减退和潜在性甲状腺功能亢进（巴塞多甲状腺功能亢进和甲状腺自主性）。根据问诊情况，应逐步进行甲状腺激素水平和促甲状腺激素水平的测定。
