Satyanarayana K, Bhaskaram P, Seshu V C, Reddy V
Am J Clin Nutr. 1980 Nov;33(11):2334-7. doi: 10.1093/ajcn/33.11.2334.
Response to BCG vaccination was studied in 261 apparently normal preschool children in a community. They were classified into different nutritional groups based on deficit in weight for age. In addition, nine children who had kwashiorkor and were admitted to the hospital were investigated. They were given 0.1 ml of BCG vaccine, and 6 months later, tuberculin sensitivity was assessed using 5 U of PPD. Blood samples were collected from 84 subjects and leukocyte migration inhibition was determined using the same antigen. After BCG vaccination, over 80% of children in the community showed positive tuberculin test, irrespective of the extent of growth retardation. There were no significant differences in the size of induration or the percentage of reactors between the various groups, indicating that the immune response to BCG vaccination is not affected by milder grades of malnutrition. However, the skin test was negative in most of the children who had had kwashiorkor. Leukocyte migration inhibition was similar in all the groups of children including those with kwashiorkor indicating that sensitisation of lymphocytes was not influenced by the nutritional status. In children with kwashiorkor, the leukocyte migration inhibition test was positive though the skin test was negative, suggesting that the former may be a better measure of assessing the response to BCG vaccination.
对某社区261名看似正常的学龄前儿童的卡介苗接种反应进行了研究。根据年龄别体重不足情况，将他们分为不同的营养组。此外，对9名患有夸希奥科病并住院的儿童进行了调查。给他们接种0.1毫升卡介苗，6个月后，使用5单位的结核菌素纯蛋白衍生物（PPD）评估结核菌素敏感性。从84名受试者采集血样，使用相同抗原测定白细胞迁移抑制情况。接种卡介苗后，该社区超过80%的儿童结核菌素试验呈阳性，无论生长发育迟缓的程度如何。各组之间硬结大小或反应者百分比均无显著差异，这表明对卡介苗接种的免疫反应不受较轻程度营养不良的影响。然而，大多数患有夸希奥科病的儿童皮肤试验呈阴性。包括患有夸希奥科病的儿童在内的所有儿童组白细胞迁移抑制情况相似，这表明淋巴细胞致敏不受营养状况影响。在患有夸希奥科病的儿童中，尽管皮肤试验呈阴性，但白细胞迁移抑制试验呈阳性，这表明前者可能是评估对卡介苗接种反应的更好指标。
