Freitag V
Med Klin. 1978 Mar 24;73(12):423-7.
The new developed antibiotic cefoxitin has been tested in vitro on its effectiveness against bacteria isolated from human material. Pseudomonas aeruginosa and streptococci of the serological group D were not tested, because these microorganisms are not sensitive against this antibiotic. Besides cefoxitin other antibiotics (cephalothin, cephalexin, ampicillin, carbenicillin, tetracycline, gentamicin, penicillin G, oxacillin) and trimethoprim-sulfamethoxazole were also tested. As to the results cefoxitin shows the best effectiveness against all gram-positive bacteria and against gram-negative bacteria including indol-positive species of proteus, providencia, serratia marcescens and the anaerobe, gram-negative, non-spore-forming rods. There are different results with enterobacter-, citrobacter-, achromobacter- and acinetobacter-species.
新研发的抗生素头孢西丁已在体外测试其对从人体材料中分离出的细菌的有效性。未对铜绿假单胞菌和血清学D组链球菌进行测试，因为这些微生物对该抗生素不敏感。除头孢西丁外，还测试了其他抗生素（头孢噻吩、头孢氨苄、氨苄西林、羧苄西林、四环素、庆大霉素、青霉素G、苯唑西林）以及甲氧苄啶-磺胺甲恶唑。就结果而言，头孢西丁对所有革兰氏阳性菌以及革兰氏阴性菌（包括变形杆菌、普罗威登斯菌、粘质沙雷氏菌的吲哚阳性菌和厌氧菌、革兰氏阴性、无芽孢杆菌）显示出最佳疗效。对于肠杆菌属、柠檬酸杆菌属、无色杆菌属和不动杆菌属细菌，结果有所不同。
