Le Bars D, Chitour D, Kraus E, Dickenson A H, Besson J M
C R Seances Acad Sci D. 1980 Sep 29;291(4):433-6.
Recording from convergent neurones--i. e. those responding to both non-noxious and noxious cutaneous stimuli--in the dorsal horn of the intact anaesthetized Rat, two distinct effects are seen after application of noxious stimuli: there is an activation of units of the segmental pool, along with a very powerful inhibition of the remaining neuronal population (diffuse noxious inhibitory controls, DNIC). Morphine at doses inadequate to directly depress the activity of these units specifically blocks the inhibition. Since DNIC is dependent upon supraspinal mechanisms, these observations show that morphine is capable of depressing certain descending inhibitory controls, at least when these are induced by noxious peripheral stimuli.
在完整麻醉大鼠的背角记录汇聚神经元——即那些对无害和有害皮肤刺激均有反应的神经元——时，施加有害刺激后可观察到两种不同的效应：节段性神经元池的神经元被激活，同时其余神经元群体受到非常强烈的抑制（弥漫性有害抑制控制，DNIC）。剂量不足以直接抑制这些神经元活动的吗啡可特异性阻断这种抑制。由于DNIC依赖于脊髓上机制，这些观察结果表明，吗啡能够抑制某些下行抑制控制，至少在这些抑制由外周有害刺激诱导时如此。
