Bouhassira D, Villanueva L, Le Bars D
Unité de Recherches de Neurophysiologie Pharmacologique de l'I.N.S.E.R.M., Paris, France.
Eur J Pharmacol. 1988 Mar 29;148(2):273-7. doi: 10.1016/0014-2999(88)90574-2.
We have proposed that a painful focus will disturb the global activity of spinal and trigeminal convergent neurones in two complementary ways: by activation of the corresponding segmental pool of neurones and by an inhibition mediated by diffuse noxious inhibitory controls of the remaining neuronal population. Morphine (10 micrograms) administered within the third ventricle blocks diffuse noxious inhibitory controls acting on a basic somesthetic activity simulated by responses of convergent neurones to innocuous stimuli. It is proposed that analgesia induced by intracerebroventricular morphine could result, at least in part, from restoration of the basic somesthetic activity.
我们提出，疼痛焦点会通过两种互补方式干扰脊髓和三叉会聚神经元的整体活动：通过激活相应节段的神经元池，以及通过对其余神经元群体的弥漫性有害抑制控制介导的抑制作用。在第三脑室内注射吗啡（10微克）可阻断弥漫性有害抑制控制，该控制作用于由会聚神经元对无害刺激的反应所模拟的基本躯体感觉活动。有人提出，脑室内注射吗啡所诱导的镇痛作用至少部分可能是由于基本躯体感觉活动的恢复。
