丙戊酸钠使人体血浆γ-氨基丁酸增加。
Increase of human plasma GABA by sodium valproate.
作者信息
Löscher W, Schmidt D
出版信息
Epilepsia. 1980 Dec;21(6):611-5. doi: 10.1111/j.1528-1157.1980.tb04314.x.
Abstract
gamma-Aminobutyric acid (GABA) was measured in the plasma of volunteers during subchronic treatment with sodium valproate (VPA). After 2 days of oral treatment with 300 mg VPA, t.i.d., the GABA concentration was increased to about 30% compared to 2 control days. This response was similar to that after 2 days of treatment with 600 mg VPA, t.i.d., whereas on the fourth day of treatment with the latter dose, a plasma GABA increase of about 90% was observed.
摘要
在志愿者接受丙戊酸钠（VPA）亚慢性治疗期间，测定了其血浆中的γ-氨基丁酸（GABA）含量。在每天口服3次、每次300mg VPA进行2天治疗后，与2个对照日相比，GABA浓度升高了约30%。这种反应与每天口服3次、每次600mg VPA治疗2天后的反应相似，而在用后一剂量治疗的第4天，观察到血浆GABA升高了约90%。
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