丙戊酸钠在大鼠中枢神经系统中的分布及GABA代谢
Distribution of sodium valproate and GABA metabolism in CNS of the rat.
作者信息
Hariton C, Ciesielski L, Simler S, Valli M, Jadot G, Gobaille S, Mesdjian E, Mandel P
出版信息
Biopharm Drug Dispos. 1984 Oct-Dec;5(4):409-14. doi: 10.1002/bdd.2510050412.
PMID:6441608
Abstract
The distribution of VPA has been investigated in several brain areas of the rat, and GABA increases were measured. A biphasic exponential decay was observed for VPA; the slowest decrease was noted in the olfactory bulbs and in the hypothalamus where GAD and GABA-T activities were the highest. The data may be correlated with the prolonged effect of VPA in these areas.
摘要
已在大鼠的几个脑区研究了丙戊酸（VPA）的分布，并测量了γ-氨基丁酸（GABA）的增加情况。观察到VPA呈双相指数衰减；在嗅球和下丘脑观察到最慢的下降，而这两个区域中谷氨酸脱羧酶（GAD）和GABA转氨酶（GABA-T）的活性最高。这些数据可能与VPA在这些区域的延长作用相关。
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