丙戊酸钠及其他抗惊厥药对大鼠肝细胞培养物的肝毒性

Hepatotoxicity of sodium valproate and other anticonvulsants in rat hepatocyte cultures.

作者信息

Kingsley E, Tweedale R, Tolman K G

出版信息

Epilepsia. 1980 Dec;21(6):699-704. doi: 10.1111/j.1528-1157.1980.tb04323.x.

DOI:10.1111/j.1528-1157.1980.tb04323.x

Abstract

Valproic acid has recently been shown to be associated with liver disease in man. Rat hepatocyte cultures were used to test the hepatotoxicity of valproic acid and several other anticonvulsants. Dose-related hepatotoxicity was demonstrated for valproic acid at concentrations ranging from 10 to 320 micrograms/ml, therapeutic concentrations being 50-100 micrograms/ml. Hepatotoxicity could not be demonstrated for phenobarbital, phenytoin, primidone, and clonazepam. It is concluded that valproic acid is a dose-related hepatotoxin.

摘要

最近有研究表明丙戊酸与人类肝脏疾病有关。利用大鼠肝细胞培养物来检测丙戊酸和其他几种抗惊厥药的肝毒性。在浓度范围为10至320微克/毫升时，丙戊酸呈现出剂量相关的肝毒性，其治疗浓度为50 - 100微克/毫升。苯巴比妥、苯妥英、扑米酮和氯硝西泮未表现出肝毒性。结论是丙戊酸是一种与剂量相关的肝毒素。