Leake E S, Wright M J, Kremkau F W
J Clin Ultrasound. 1980 Dec;8(6):465-72. doi: 10.1002/jcu.1870080604.
Rabbit alveolar macrophages in suspension were exposed to 5 or 10 min of continuous 2-MHz ultrasound with 5, 10, and 15 W/cm2 spatial average intensities. Viability as determined by dye exclusion decreased with increasing intensity. Pressure experiments indicated that this was a result of acoustic cavitation. Ultrasound induced clumping of cells and often reduced membrane ruffling. Some cells were disintegrated. Cells that appeared to be otherwise intact had swollen mitochondria with ruptured cristae.
将悬浮的兔肺泡巨噬细胞暴露于连续2兆赫超声下5或10分钟，空间平均强度分别为5、10和15瓦/平方厘米。通过染料排斥法测定的细胞活力随强度增加而降低。压力实验表明这是声空化的结果。超声诱导细胞聚集，并常常减少膜褶皱。一些细胞解体。看似完好无损的细胞线粒体肿胀，嵴破裂。
