淋病奈瑟菌在豚鼠皮下腔室模型中的免疫原性复杂性。

The complexity of immunogenicity of Neisseria gonorrhoeae in the guinea pig subcutaneous chamber model.

作者信息

Parsons N J, Penn C W, Veale D R, Smith H

出版信息

J Gen Microbiol. 1980 Jun;118(2):523-7. doi: 10.1099/00221287-118-2-523.

Abstract

The immunogenicity of Neisseria gonorrhoeae in the guinea pig subcutaneous chamber model, assessed by serum bactericidal tests and challenge experiments, is complicated by diversity of immunotypes which may or may not show partial cross-reactions, by the need for antibodies to more than one type-specific antigen for full homologous protection, and possibly by the limited accessibility of the relevant antigens on the cell surface.

摘要

通过血清杀菌试验和攻毒实验评估，淋病奈瑟菌在豚鼠皮下腔室模型中的免疫原性较为复杂，这是由于免疫型的多样性（可能显示或不显示部分交叉反应）、需要针对多种型特异性抗原的抗体才能实现完全同源保护，以及细胞表面相关抗原的可及性可能有限。