Kiesling V J, McAninch J W, Goebel J L, Agee R E
J Urol. 1980 Dec;124(6):851-4. doi: 10.1016/s0022-5347(17)55697-9.
Post-irradiation biopsies were done on 68 patients who had received curative external beam radiation therapy for adenocarcinoma of the prostate. These patients were evaluated to determine subsequent rates of disease progression and patients survival. Mean followup was 5 years. Results revealed that 1) residual tumor present 12 months after therapy does not disappear, 2) advance in tumor grade occurred in 19 of 39 patients (49 per cent) with positive biopsies after therapy, 3) patients who had positive biopsies after therapy had a greater chance for disease progression (11 of 39 cases or 28 per cent) than patients with negative biopsies (4 of 29 cases or 14 per cent) and 4) hormonal therapy started when a positive biopsy was obtained appears to delay onset of disese progression.
对68例接受前列腺腺癌根治性外照射放疗的患者进行了放疗后活检。对这些患者进行评估以确定随后的疾病进展率和患者生存率。平均随访时间为5年。结果显示：1）治疗后12个月仍存在的残留肿瘤未消失；2）治疗后活检阳性的39例患者中有19例（49%）肿瘤分级进展；3）治疗后活检阳性的患者比活检阴性的患者疾病进展的可能性更大（39例中的11例，即28%，对比29例中的4例，即14%）；4）活检阳性时开始的激素治疗似乎可延迟疾病进展的发生。
