Rawlins J N, Feldon J, Salmon P, Gray J A, Garrud P
Psychopharmacology (Berl). 1980;70(3):317-22. doi: 10.1007/BF00427894.
Rats were trained to lever press for sucrose on a random interval (RI) 64-s schedule. During a 55 min session there were four 3 min "intrusion periods" signalled by a flashing house-light. In experiment 1 there were two groups matched for baseline response rate. During the intrusion periods one group received response-independent footshock on an independent RI 64 schedule; the other group received response-contingent shock on this schedule. Shock intensity was varied for each rat to match degree of response suppression between the two groups. Chlordiazepoxide HCl (CDP) in doses 0.5-5 mg/kg alleviated response suppression equally in both groups. Experiment II followed the same procedure, except that all animals had the same shock intensity, producing greater response suppression in the response-contingent shock groups. CDP alleviated response suppression more in the response-contingent shock groups, significantly so at 5 mg/kg, nonsignificantly at 1 mg/kg. These results suggest that previous reports that CDP differentially alleviates the response suppression produced by response-contingent shock are an artefact of rate dependency.
大鼠被训练在随机间隔（RI）64秒的时间表上按压杠杆以获取蔗糖。在55分钟的实验过程中，有四个3分钟的“干扰期”，由闪烁的室内灯光发出信号。在实验1中，有两组在基线反应率上进行了匹配。在干扰期，一组在独立的RI 64时间表上接受与反应无关的足部电击；另一组在该时间表上接受与反应相关的电击。为使两组之间的反应抑制程度相匹配，对每只大鼠的电击强度进行了调整。剂量为0.5 - 5毫克/千克的盐酸氯氮卓（CDP）在两组中均能同等程度地减轻反应抑制。实验II遵循相同的程序，只是所有动物的电击强度相同，这在与反应相关的电击组中产生了更大的反应抑制。CDP在与反应相关的电击组中更能减轻反应抑制，在5毫克/千克时效果显著，在1毫克/千克时效果不显著。这些结果表明，先前关于CDP能不同程度减轻与反应相关电击所产生的反应抑制的报道是速率依赖性的假象。
