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美司钠用于抑制环磷酰胺、异环磷酰胺及其他氮杂磷环类细胞抑制剂的尿路毒性副作用的研发。

The development of mesna for the inhibition of urotoxic side effects of cyclophosphamide, ifosfamide, and other oxazaphosphorine cytostatics.

作者信息

Brock N

出版信息

Recent Results Cancer Res. 1980;74:270-8. doi: 10.1007/978-3-642-81488-4_32.

DOI:10.1007/978-3-642-81488-4_32
PMID:6777836
Abstract

Urotoxic side effects on the kidneys and urinary bladder are a limiting factor in chemotherapy with oxazaphosphorine cytostatics such as cyclophosphamide and ifosfamide. Acrolein was found to be the causative factor which is spontaneously formed in the urine from the primary metabolites eliminated via the kidneys. Sodium 2-mercaptoethanesulfonate (INN: mesna) enables regional detoxification of acrolein in the kidneys and deferent urinary tract. The author reports on the pharmacotherapeutic bases and the mechanism of action of this new combination therapy and its clinical results. The untoward urotoxic side effects can be avoided with mesna without interfering with the chemotherapeutic effect on the tumor.

摘要

氧氮磷啶类细胞抑制剂（如环磷酰胺和异环磷酰胺）化疗时，对肾脏和膀胱的泌尿毒性副作用是一个限制因素。已发现丙烯醛是致病因素，它由经肾脏排出的主要代谢产物在尿液中自发形成。2-巯基乙烷磺酸钠（国际非专利药品名称：美司钠）可使肾脏和输尿管中丙烯醛进行局部解毒。作者报告了这种新联合疗法的药物治疗基础、作用机制及其临床结果。使用美司钠可避免不良泌尿毒性副作用，且不干扰对肿瘤的化疗效果。

相似文献

1
The development of mesna for the inhibition of urotoxic side effects of cyclophosphamide, ifosfamide, and other oxazaphosphorine cytostatics.美司钠用于抑制环磷酰胺、异环磷酰胺及其他氮杂磷环类细胞抑制剂的尿路毒性副作用的研发。
Recent Results Cancer Res. 1980;74:270-8. doi: 10.1007/978-3-642-81488-4_32.
2
Acrolein, the causative factor of urotoxic side-effects of cyclophosphamide, ifosfamide, trofosfamide and sufosfamide.丙烯醛是环磷酰胺、异环磷酰胺、曲磷胺和硫磷酰胺产生泌尿毒性副作用的致病因素。
Arzneimittelforschung. 1979;29(4):659-61.
3
Prevention of urotoxic side effects by regional detoxification with increased selectivity of oxazaphosphorine cytostatics.通过提高氧氮磷杂环类细胞抑制剂的选择性进行局部解毒来预防泌尿毒性副作用。
IARC Sci Publ. 1986(78):269-79.
4
Detoxification of urotoxic oxazaphosphorines by sulfhydryl compounds.巯基化合物对尿毒性氮杂磷类化合物的解毒作用。
J Cancer Res Clin Oncol. 1981;100(3):311-20. doi: 10.1007/BF00410691.
5
The efficacy of mesna (2-mercaptoethane sodium sulfonate) as a uroprotectant in patients with hemorrhagic cystitis receiving further oxazaphosphorine chemotherapy.美司钠（2-巯基乙烷磺酸钠）作为尿路保护剂在接受进一步氮杂磷类化疗的出血性膀胱炎患者中的疗效。
J Clin Oncol. 1987 May;5(5):799-803. doi: 10.1200/JCO.1987.5.5.799.
6
Effect of the uroprotector sodium 2-mercaptoethane sulfonate (Mesna) on the proliferation of the bladder urothelium in the rat after administration of cyclophosphamide.巯乙磺酸钠（美司钠）对环磷酰胺给药后大鼠膀胱尿路上皮增殖的影响。
Urol Int. 1984;39(2):61-7. doi: 10.1159/000280947.
7
[Prevention of urotoxic complications during therapy with cytostatics. The problem of the interaction between sodium-II-mercaptoethanesulfonate and cyclophosphamide].[细胞抑制剂治疗期间泌尿毒性并发症的预防。2-巯基乙烷磺酸钠与环磷酰胺相互作用的问题]
Fortschr Med. 1981 Oct 22;99(40):1650-2.
8
Clinical overview of mesna.美司钠的临床概述
Cancer Treat Rev. 1983 Sep;10 Suppl A:175-81. doi: 10.1016/s0305-7372(83)80026-7.
9
Ifosfamide and mesna.
Clin Pharm. 1990 Mar;9(3):179-91.
10
Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention--III. Profile of action of sodium 2-mercaptoethane sulfonate (mesna).氮杂磷三环类细胞抑制剂的尿路毒性及其预防研究——III. 2-巯基乙烷磺酸钠（美司钠）的作用概况。
Eur J Cancer Clin Oncol. 1982 Dec;18(12):1377-87. doi: 10.1016/0277-5379(82)90143-2.

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Late effects on the urinary bladder in patients treated for cancer in childhood: a report from the Children's Oncology Group.
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4
Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals.O6-甲基鸟嘌呤-DNA甲基转移酶在保护细胞和动物免受环磷酰胺诱导的毒性中的作用。
DNA Repair (Amst). 2007 Aug 1;6(8):1145-54. doi: 10.1016/j.dnarep.2007.03.010. Epub 2007 May 7.
5
Mesnum as a protector against kidney and bladder toxicity with high-dose ifosfamide treatment.
Cancer Chemother Pharmacol. 1982;9(2):81-4. doi: 10.1007/BF00265383.
6
Flow-cytophotometric studies on urine sediments of patients treated with anti-cancer-drugs.对接受抗癌药物治疗患者的尿沉渣进行的流式细胞光度研究。
Urol Res. 1983;11(4):159-62. doi: 10.1007/BF00256363.
7
Formation, toxicity and inactivation of acrolein during biotransformation of cyclophosphamide as studied in freshly isolated cells from rat liver and kidney.在从大鼠肝脏和肾脏新鲜分离的细胞中研究环磷酰胺生物转化过程中丙烯醛的形成、毒性及失活
Arch Toxicol. 1985 Jun;57(2):99-103. doi: 10.1007/BF00343118.
8
Effective prevention of the nephrotoxicity of cis-platin (CDDP) by administration of sodium 2-mercaptoethane-sulfonate (MESNA) in rats.通过给大鼠施用2-巯基乙烷磺酸钠（MESNA）有效预防顺铂（CDDP）的肾毒性。
Br J Cancer. 1985 Dec;52(6):937-9. doi: 10.1038/bjc.1985.280.
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Carcinogenic effect of cisplatin (cis-diammine-dichloroplatinum (II), CDDP) in BD IX rats.顺铂（顺二氨二氯铂（II），CDDP）对BD IX大鼠的致癌作用。
J Cancer Res Clin Oncol. 1986;111(2):133-6. doi: 10.1007/BF00400751.