Pento J T
Res Commun Chem Pathol Pharmacol. 1980 Nov;30(2):233-41.
Theophylline (5mM) produced a two-fold rise in calcitonin release from porcine thyroid slices; however, tissue uptake of 45Ca was not affected by theophylline. The calcium antagonists D-600 (5mM) and cobalt (5mM) which reduced the total tissue and cell associated 45Ca spaces in this incubation system were found to reduce theophylline-stimulated calcitonin release. Cobalt produced a greater reduction in tissue uptake of 45Ca and also reduced basal calcitonin secretion. The results suggest that calcium is necessary for theophylline-mediated calcitonin secretion.
茶碱（5毫摩尔）使猪甲状腺切片中降钙素的释放增加了两倍；然而，45钙的组织摄取不受茶碱影响。在该孵育系统中，能减少总组织和细胞相关45钙空间的钙拮抗剂D-600（5毫摩尔）和钴（5毫摩尔），被发现可减少茶碱刺激的降钙素释放。钴对45钙的组织摄取减少得更多，同时也降低了基础降钙素分泌。结果表明，钙对于茶碱介导的降钙素分泌是必需的。
