Selawry H P, Becker K L, Bivins L E, Snider R H, Silva O L
Horm Metab Res. 1975 Sep;7(5):432-7. doi: 10.1055/s-0028-1093700.
The influence of various agents on calcitonin release from human thyroid was studied in vitro. Under the condition of this investigation, calcium, magnesium and phosphate did not stimulate calcitonin release from short-term incubated slices of human thyroid. However, pentagastrin and USP glucagon were potent stimulators of calcitonin release. Theophylline and dibutyryl cyclic AMP were also potent stimuli. A highly purified preparation of pancreatic glucagon was without an effect. Those agents which stimulated calcitonin release were associated with augmented cyclic AMP accumulation. Although maximal discharge of calcitonin required the presence of calcium, out in vitro experiments raise the question as to whether a gastrointestinal hormone, rather than calcium, might not be the principal agent affecting calcitonin release.
在体外研究了各种因素对人甲状腺降钙素释放的影响。在本研究条件下，钙、镁和磷酸盐不会刺激人甲状腺短期孵育切片释放降钙素。然而，五肽胃泌素和美国药典胰高血糖素是降钙素释放的有效刺激物。茶碱和二丁酰环磷腺苷也是有效的刺激物。高纯度的胰高血糖素制剂没有作用。那些刺激降钙素释放的因素与环磷腺苷积累增加有关。虽然降钙素的最大释放需要钙的存在，但我们的体外实验提出了一个问题，即影响降钙素释放的主要因素是否可能不是钙，而是一种胃肠激素。
