2'-硫脲对大鼠的致畸作用。

Teratogenic effect of 2'-thiourea in the rat.

作者信息

Kern M, Tatár-Kiss Z, Kertai P, Földes I

出版信息

Acta Morphol Acad Sci Hung. 1980;28(3):259-67.

Abstract

The compound 2'-thiourea was studied for teratogenic effect in fetal rats. A 0.2% aqueous solution of 2'-thiourea (Merck) was administered ad libitum to pregnant rats from the first to the 14th day of pregnancy. The pregnancy was counted from the day when sperm was found in the vaginal smear. In the treated rat fetuses hypoplasia of the brain and spinal cord, internal hydrocephalus, hypoplasia of the spinal ganglia, kypholordosis, micromelia, micrognathia, cleft palate, retarded tooth development, exophthalmus, coloboma, and cataract were observed. In addition, generalized haemorrhages were found all over the body. The changes were similar to those produced by ethylene thiourea treatment in rat fetuses.

摘要

研究了化合物2'-硫脲对胎鼠的致畸作用。在妊娠第1天至第14天，给怀孕大鼠随意饮用0.2%的2'-硫脲（默克公司）水溶液。妊娠从在阴道涂片发现精子的那天开始计算。在接受治疗的大鼠胎儿中，观察到脑和脊髓发育不全、脑积水、脊髓神经节发育不全、脊柱后凸、短肢、小颌、腭裂、牙齿发育迟缓、眼球突出、缺损和白内障。此外，在全身发现了广泛性出血。这些变化与乙烯硫脲处理大鼠胎儿所产生的变化相似。