Engel J, Wolfson L, Brown L
Ann Neurol. 1978 Jun;3(6):538-44. doi: 10.1002/ana.410030615.
Anatomical structures demonstrating increased glucose uptake during the various stages of amygdaloid kindling in rats were identified by the 14C-2-deoxyglucose (DG) autoradiographic technique. Partial (stages 1 and 2) seizures were correlated with increased DG uptake in the ipsilateral amygdala and its direct projection fields. The appearance of generalized motor (stages 3,4, and 5) seizures was accompanied by less limbic involvement and recruitment of a bilateral system including substantia nigra, specific and nonspecific thalamic nuclei, globus pallidus, and neocortex. Increased hippocampal DG uptake was correlated with prolonged amygdaloid after discharge duration but not with the behavioral seizure stage. This study does not reveal which of these structures are responsible for the observed behavioral and electrical events and which are activated by them. It does suggest, however, that three discrete anatomical systems underlie the generation of partial seizures, generalized motor seizures, and local after discharge.
采用¹⁴C-2-脱氧葡萄糖（DG）放射自显影技术，确定了大鼠杏仁核点燃各阶段葡萄糖摄取增加的解剖结构。部分（第1和2阶段）癫痫发作与同侧杏仁核及其直接投射区域的DG摄取增加相关。全身性运动性（第3、4和5阶段）癫痫发作的出现伴随着边缘系统受累减少以及包括黑质、特异性和非特异性丘脑核、苍白球和新皮质在内的双侧系统的激活。海马DG摄取增加与杏仁核放电后持续时间延长相关，但与行为性癫痫发作阶段无关。本研究未揭示这些结构中哪些是所观察到的行为和电活动的原因，哪些是由它们激活的。然而，它确实表明，三个离散的解剖系统是部分性癫痫发作、全身性运动性癫痫发作和局部放电后发作产生的基础。
