Laznikova T N, Krasnova T P, Lipina E V, Orlova N V
Antibiotiki. 1978 Jun;23(6):499-503.
Dependence of biosynthesis of gentamicin and vitamin B12 on complex and "synthetic" media under conditions of decreased aeration, increased phosphorus levels and non-optimal content of carbon source was studied. The decreased levels of vitamin B12 production under conditions of the non-optimal content of the carbon source and increased phosphorus levels in the medium resulted in decreased production of the antibiotic complex as a whole and decreased relative content of the most methylated gentamicins C1 and C2 in the complex. Decreased aeration lowered the mycelium productivity with respect to the antibiotic production without changing the ratio of the components in the complex and the level of vitamin B12 production.
在通气减少、磷水平增加以及碳源含量非最佳的条件下，研究了庆大霉素和维生素B12的生物合成对复杂培养基和“合成”培养基的依赖性。在碳源含量非最佳和培养基中磷水平增加的条件下，维生素B12产量降低，导致整个抗生素复合物产量下降，且复合物中甲基化程度最高的庆大霉素C1和C2的相对含量降低。通气减少降低了菌丝体产生抗生素的生产力，但不改变复合物中各组分的比例以及维生素B12的产量水平。
