Krasnova T P, Laznikova T N, Orlova N V
Antibiotiki. 1977 Mar;22(3):201-6.
The effect of cobalt on growth of Micromonospora purpurea var. violacea 1935 and biosynthess of gentamicin in complex soy-bean meal or "synthetic" gelatin medium was studied. In optimal concentrations cobalt increased the activity level of the culture fluid almost 6 times in both media having practically no effect on the amount of the mycelium formed. Addition of cobalt to the medium resulted in retardation of the organism growth and consumption of the nutrients. Stimulation of gentamicin biosynthesis by cobalt was inversely proportional to the time of the trace element addition. The cobalt effect depended on the aeration conditions, inorganic phosphorus level in the medium and physiological condition of the mycelium.
研究了钴对紫色小单孢菌变种紫1935生长以及在复合豆粕或“合成”明胶培养基中庆大霉素生物合成的影响。在最佳浓度下，钴使两种培养基中培养液的活性水平提高了近6倍，而对形成的菌丝体量几乎没有影响。向培养基中添加钴会导致生物体生长延迟和营养物质消耗。钴对庆大霉素生物合成的刺激作用与微量元素添加时间成反比。钴的作用取决于通气条件、培养基中的无机磷水平和菌丝体的生理状态。
