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Metabolism of benzo(a)pyrene by isolated hepatocytes and factors affecting covalent binding of benzo(a)pyrene metabolites to DNA in hepatocyte and microsomal systems.

作者信息

Shen A L, Fahl W E, Jefcoate C R

出版信息

Arch Biochem Biophys. 1980 Oct 15;204(2):511-23. doi: 10.1016/0003-9861(80)90063-6.

DOI:10.1016/0003-9861(80)90063-6
PMID:6778394
Abstract
摘要

相似文献

1
Metabolism of benzo(a)pyrene by isolated hepatocytes and factors affecting covalent binding of benzo(a)pyrene metabolites to DNA in hepatocyte and microsomal systems.苯并(a)芘在分离的肝细胞中的代谢以及影响苯并(a)芘代谢产物在肝细胞和微粒体系统中与DNA共价结合的因素。
Arch Biochem Biophys. 1980 Oct 15;204(2):511-23. doi: 10.1016/0003-9861(80)90063-6.
2
Fluorescence study of DNA-binding metabolites of benzo(a)pyrene formed in hepatocytes isolated from 3-methylcholanthrene-treated rats.从经3-甲基胆蒽处理的大鼠分离出的肝细胞中形成的苯并(a)芘DNA结合代谢物的荧光研究。
Cancer Res. 1978 Aug;38(8):2600-7.
3
Kinetic determinants of benzo[a]pyrene metabolism to dihydrodiol epoxides by 3-methylcholanthrene-induced rat liver microsomes.3-甲基胆蒽诱导的大鼠肝微粒体将苯并[a]芘代谢为二氢二醇环氧化物的动力学决定因素。
Mol Pharmacol. 1982 Sep;22(2):451-8.
4
Kinetic analysis of the metabolism of benzo(a)pyrene to phenols, dihydrodiols, and quinones by high-pressure chromatography compared to analysis by aryl hydrocarbon hydroxylase assay, and the effect of enzyme induction.通过高压色谱法对苯并(a)芘代谢为酚类、二氢二醇和醌类的动力学分析与通过芳烃羟化酶测定法的分析比较，以及酶诱导的影响。
Cancer Res. 1975 Dec;35(12):3642-50.
5
Reduction of epoxy derivatives of benzo(a)pyrene by microsomal cytochrome P-450.微粒体细胞色素P-450对苯并(a)芘环氧衍生物的还原作用。
Cancer Res. 1980 Aug;40(8 Pt 1):2910-4.
6
Effect of UDP-glucuronic acid on the microsome-mediated binding of benzo(a)pyrene metabolites to calf thymus DNA.尿苷二磷酸葡萄糖醛酸对苯并(a)芘代谢物与小牛胸腺 DNA 微粒体介导结合的影响。
Carcinogenesis. 1980 Feb;1(2):115-20. doi: 10.1093/carcin/1.2.115.
7
Specificity of chemiluminescence in the metabolism of benzo[a]pyrene to its carcinogenic diol epoxide.苯并[a]芘代谢为其致癌二醇环氧化物过程中化学发光的特异性。
Proc Natl Acad Sci U S A. 1981 Feb;78(2):940-2. doi: 10.1073/pnas.78.2.940.
8
Formation of DNA-binding products from isolated benzo[a]pyrene metabolites in rat liver nuclei.
Chem Biol Interact. 1978 Mar;20(3):311-21. doi: 10.1016/0009-2797(78)90109-6.
9
Covalent binding of benzo[a]pyrene to rat liver cytosolic proteins and its effect on the binding to microsomal proteins.苯并[a]芘与大鼠肝脏胞质蛋白的共价结合及其对微粒体蛋白结合的影响。
Biochem Pharmacol. 1983 May 1;32(9):1501-6. doi: 10.1016/0006-2952(83)90472-0.
10
Magnesium ions affect the quantitative but not the qualitative microsome mediated binding of benzo[alpha]-pyrene to DNA.镁离子影响苯并[a]芘与DNA的微粒体介导结合的定量，但不影响其定性。
Chem Biol Interact. 1979 Dec;28(2-3):279-89. doi: 10.1016/0009-2797(79)90168-6.

引用本文的文献

1
Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA.在谷胱甘肽介导的致癌物1,2 - 二溴乙烷与DNA的结合中形成S-[2-(N7-鸟嘌呤基)乙基]谷胱甘肽加合物的证据。
Proc Natl Acad Sci U S A. 1983 Sep;80(17):5266-70. doi: 10.1073/pnas.80.17.5266.
2
Chemical carcinogenesis in feral fish: uptake, activation, and detoxication of organic xenobiotics.野生鱼类中的化学致癌作用：有机外源化合物的摄取、活化与解毒
Environ Health Perspect. 1987 Apr;71:155-70. doi: 10.1289/ehp.8771155.
3
Hepatic activities of xenobiotic metabolizing enzymes and biliary levels of xenobiotics in English sole (Parophrys vetulus) exposed to environmental contaminants.
暴露于环境污染物的星斑川鲽（Parophrys vetulus）中异生物质代谢酶的肝脏活性及异生物质的胆汁水平。
Arch Environ Contam Toxicol. 1991 May;20(4):462-73. doi: 10.1007/BF01065834.