用D，L-α-二氟甲基鸟氨酸处理使9L大鼠脑肿瘤细胞的多胺含量耗竭，可抑制细胞增殖及G1期到S期的转变。 - Suppr

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超能文献

Depletion of 9L rat brain tumor cell polyamine content by treatment with D,L-alpha-difluoromethylornithine inhibits proliferation and the G1 to S transition.

作者信息

Seidenfeld J, Gray J W, Marton L J

出版信息

Exp Cell Res. 1981 Jan;131(1):209-16. doi: 10.1016/0014-4827(81)90420-1.

DOI:10.1016/0014-4827(81)90420-1

PMID:6778484

Abstract

摘要

相似文献

Depletion of 9L rat brain tumor cell polyamine content by treatment with D,L-alpha-difluoromethylornithine inhibits proliferation and the G1 to S transition.用D，L-α-二氟甲基鸟氨酸处理使9L大鼠脑肿瘤细胞的多胺含量耗竭，可抑制细胞增殖及G1期到S期的转变。

Exp Cell Res. 1981 Jan;131(1):209-16. doi: 10.1016/0014-4827(81)90420-1.

Depletion of intracellular putrescine and spermidine by alpha-difluromethylornithine does not inhibit proliferation of 9L rat brain tumor cells.α-二氟甲基鸟氨酸耗尽细胞内的腐胺和亚精胺并不抑制9L大鼠脑肿瘤细胞的增殖。

Biochem Biophys Res Commun. 1979 Feb 28;86(4):1192-8. doi: 10.1016/0006-291x(79)90243-2.

Effects of polyamine depletion on proliferation and differentiation of murine erythroleukemia cells.多胺耗竭对小鼠红白血病细胞增殖和分化的影响。

Cancer Res. 1984 Apr;44(4):1440-4.

The role of polyamine depletion and accumulation of decarboxylated S-adenosylmethionine in the inhibition of growth of SV-3T3 cells treated with alpha-difluoromethylornithine.多胺耗竭和脱羧S-腺苷甲硫氨酸的积累在α-二氟甲基鸟氨酸处理的SV-3T3细胞生长抑制中的作用

Biochem J. 1984 Nov 15;224(1):29-38. doi: 10.1042/bj2240029.

Effects of DL-alpha-methylornithine on proliferation and polyamine content of 9L rat brain tumor cells.DL-α-甲基鸟氨酸对9L大鼠脑肿瘤细胞增殖和多胺含量的影响。

Cancer Res. 1980 Jun;40(6):1961-6.

Depletion of intracellular polyamines may alter DNA conformation in 9L rat brain tumor cells.细胞内多胺的耗尽可能会改变9L大鼠脑肿瘤细胞中的DNA构象。

Science. 1983 Jul 22;221(4608):368-70. doi: 10.1126/science.6408733.

Polyamines in brain and heart of the neonatal rat: effects of inhibitors of ornithine decarboxylase and spermidine synthase.新生大鼠脑和心脏中的多胺：鸟氨酸脱羧酶和亚精胺合酶抑制剂的作用。

Life Sci. 1984 Sep 3;35(10):1125-31. doi: 10.1016/0024-3205(84)90078-x.

Sensitization of 9L rat brain gliosarcoma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor.鸟氨酸脱羧酶抑制剂α-二氟甲基鸟氨酸使9L大鼠脑胶质肉瘤细胞对1,3-双（2-氯乙基）-1-亚硝基脲敏感化。

Cancer Res. 1981 Jul;41(7):2783-5.

Polyamines in 1 alpha, 25-dihydroxycholecalciferol-induced differentiation of human promyelocytic leukemia cells, HL-60.多胺在1α,25 - 二羟基胆钙化醇诱导的人早幼粒细胞白血病细胞HL - 60分化中的作用

Endocrinology. 1986 May;118(5):1849-55. doi: 10.1210/endo-118-5-1849.

Indirect evidence for a strict negative control of S-adenosyl-L-methionine decarboxylase by spermidine in rat hepatoma cells.在大鼠肝癌细胞中，亚精胺对S-腺苷-L-甲硫氨酸脱羧酶进行严格负调控的间接证据。

Biochem J. 1981 May 15;196(2):411-22. doi: 10.1042/bj1960411.

引用本文的文献

Upregulation of Polyamine Transport in Human Colorectal Cancer Cells.多胺转运在人结直肠癌细胞中的上调。

Biomolecules. 2020 Mar 25;10(4):499. doi: 10.3390/biom10040499.

Polyamine-DNA Interactions: Possible Site of New Cancer Chemotherapeutic Intervention.多胺与 DNA 的相互作用：新的癌症化学治疗干预的可能靶点。

Pharm Res. 1986 Dec;3(6):311-7. doi: 10.1023/A:1016375705487.

Role of p53/p21(Waf1/Cip1) in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells.p53/p21（Waf1/Cip1）在多胺类似物诱导人乳腺癌细胞生长抑制和细胞死亡调控中的作用

Cancer Biol Ther. 2005 Sep;4(9):1006-13. doi: 10.4161/cbt.4.9.1970. Epub 2005 Sep 23.

The effect of DFMO induced uptake of [3H] putrescine on human glioma cells.二氟甲基鸟氨酸（DFMO）诱导的[3H]腐胺摄取对人胶质瘤细胞的影响。

J Neurooncol. 2001 Nov;55(2):71-80. doi: 10.1023/a:1013348227892.

Enhanced uptake of [3H] spermidine by 9L rat brain tumors after direct intratumoral infusion of inhibitors of enzymes of the polyamine biosynthetic pathway.在向9L大鼠脑肿瘤内直接注射多胺生物合成途径中酶的抑制剂后，[3H]亚精胺在肿瘤中的摄取增加。

J Neurooncol. 1999 Apr;42(2):123-30. doi: 10.1023/a:1006108321223.

Phase II trial of recombinant interferon-alpha-2a and eflornithine in patients with recurrent glioma.重组干扰素α-2a与依氟鸟氨酸治疗复发性胶质瘤的II期试验

J Neurooncol. 1998 Jan;36(1):65-70. doi: 10.1023/a:1005870329601.

Excess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis.多胺腐胺的过量积累会抑制修饰型真核起始因子5A（eIF-5A）的形成并诱导细胞凋亡。

Biochem J. 1997 Dec 15;328 ( Pt 3)(Pt 3):847-54. doi: 10.1042/bj3280847.

Polyamines in brain tumor therapy.脑肿瘤治疗中的多胺

J Neurooncol. 1995;25(2):167-79. doi: 10.1007/BF01057761.

Cytosolic and nuclear spermidine acetyltransferases in growing NIH 3T3 fibroblasts stimulated with serum or polyamines: relationship to polyamine-biosynthetic decarboxylases and histone acetyltransferase.血清或多胺刺激下生长的NIH 3T3成纤维细胞中的胞质和核精胺乙酰转移酶：与多胺生物合成脱羧酶和组蛋白乙酰转移酶的关系

Biochem J. 1993 Jul 15;293 ( Pt 2)(Pt 2):475-9. doi: 10.1042/bj2930475.

Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival, and cell cycle progression in two human brain tumor cell lines.两种多胺类似物（BE-4-4-4和BE-4-4-4-4）直接影响两种人脑肿瘤细胞系的生长、存活及细胞周期进程。

Cancer Chemother Pharmacol. 1995;36(5):411-7. doi: 10.1007/BF00686190.

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