Slavin A A, Etingov E D, Ostrovskiĭ M V, Varlashina V M, Korotkhaia L V
Antibiotiki. 1978 Jul;23(7):626-9.
A marked decrease in the coefficient of oleandomycin distribution in the system of the fermentation broth filtrate-butyl acetate was observed during the transfer from the 1st to the following extraction stages. It was supposed that the oleandomycin fermentation broth filtrate contained admixtures affecting significantly the antibiotic distribution between the aqueous phase and organic solvent.
在从第一级萃取阶段转移至后续萃取阶段的过程中,观察到发酵滤液 - 乙酸丁酯体系中竹桃霉素的分配系数显著降低。据推测,竹桃霉素发酵滤液中含有一些杂质,这些杂质会显著影响抗生素在水相和有机溶剂之间的分配。